Multinuclear Fingerprinting

Overview

In this project, we are developing a noninvasive technique based on magnetic resonance imaging (MRI), that can generate quantitative and multi-parametric structural and metabolic maps of the whole living human brain.

The method is called multinuclear fingerprinting (MNF) and is based on the simultaneous acquisition of hydrogen (1H, from water molecules) and sodium (23Na, from Na+ ions) data via magnetic resonance fingerprinting (MRF), combined with a super-resolution algorithm. These new maps have the potential to provide new insights into brain morphology, physiology, and their interconnection, better understanding of which is crucial for to the advancement of knowledge about the human brain and its disorders. MRI scans are performed at 7 T.

Keywords
  • Multinuclear Fingerprinting (MNF)
  • Simultaneous 1H/23Na MRF
Project Team
Guillaume Madelin, PhD

Project Lead

Publications

  1. Rodriguez GG, Yu Z, Shaykevich S, et al. Super-resolution of sodium images from simultaneous 1 H MRF/23 Na MRI acquisition. NMR Biomed. 2023;36(10):e4959. doi:10.1002/nbm.4959
  2. Chubak I, Alon L, Silletta EV, Madelin G, Jerschow A, Rotenberg B. Quadrupolar 23Na+ NMR relaxation as a probe of subpicosecond collective dynamics in aqueous electrolyte solutions. Nat Commun. 2023;14(1):84. Published 2023 Jan 5. doi:10.1038/s41467-022-35695-3
  3. Rodriguez GG, Yu Z, O Donnell LF, Calderon L, Cloos MA, Madelin G. Repeatability of simultaneous 3D 1H MRF/23Na MRI in brain at 7 T. Sci Rep. 2022;12(1):14156. Published 2022 Aug 19. doi:10.1038/s41598-022-18388-1
  4. Yu Z, Hodono S, Dergachyova O, et al. Simultaneous 3D acquisition of 1 H MRF and 23 Na MRI. Magn Reson Med. 2022;87(5):2299-2312. doi:10.1002/mrm.29135
  5. Wang B, Zhang B, Yu Z, et al. A radially interleaved sodium and proton coil array for brain MRI at 7 T. NMR Biomed. 2021;34(12):e4608. doi:10.1002/nbm.4608
  6. Yu Z, Madelin G, Sodickson DK, Cloos MA. Simultaneous proton magnetic resonance fingerprinting and sodium MRI. Magn Reson Med. 2020;83(6):2232-2242. doi:10.1002/mrm.28073
  7. Silletta EV, Jerschow A, Madelin G, Alon L. Multinuclear absolute magnetic resonance thermometry. Commun Phys. 2019;2:152. doi:10.1038/s42005-019-0252-3

Acknowledgements

This project is supported by National Institute of Health (NIH): NIH R01EB026456 (PI: G.Madelin), “Simultaneous multinuclear magnetic resonance fingerprinting for data fusion of quantitative structural and metabolic imaging”.

Researchers at the Center for Biomedical Imaging at NYU Langone Health develop transformative imaging technologies to advance basic science and address unsolved clinical problems.

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