Multinuclear MRI to Monitor Breast Cancer Therapy

Overview

In this project we are developing a multinuclear magnetic resonance imaging (MRI) technique to provide information about early response of breast cancer to neoadjuvant chemotheraphy (NACT).

NACT is administered to treat locally advanced invasive breast cancer. The goal of the treatment is to shrink inoperable tumors and to enable breast-conserving surgery. NACT offers the opportunity to evaluate tumor response to treatment in aggressive disease, and early identification of responders versus non-responders can aid the identification of patients who could benefit from additional trials.

In the study, we implement a quantitative multinuclear MRI protocol based on simultaneous acquisitions of sodium (23Na) and hydrogen (1H) MR fingerprinting data to develop an imaging biomarker model of early response of breast cancer to NACT. MRI scans are performed at 3 T.

Keywords
  • Multinuclear MRI
  • Breast cancer
  • Neoadjuvant chemotherapy (NACT)
Project Team
Guillaume Madelin, PhD

Project Lead

Baptiste Busi, PhD
Linda Moy, MD
Ryan Brown, PhD

Project Lead

Bernhard Gruber, PhD
External Collaborators

Publications

  1. Ianniello C, Moy L, Fogarty J, et al. Multinuclear MRI to disentangle intracellular sodium concentration and extracellular volume fraction in breast cancer. Sci Rep. 2021;11(1):5156. Published 2021 Mar 4. doi:10.1038/s41598-021-84616-9
  2. Ianniello C, Madelin G, Moy L, Brown R. A dual-tuned multichannel bilateral RF coil for 1 H/23 Na breast MRI at 7 T. Magn Reson Med. 2019;82(4):1566-1575. doi:10.1002/mrm.27829

Acknowledgements

We acknowledge support from the following NIH grants: NIH R01CA266345, NIH R21CA213169.

Researchers at the Center for Biomedical Imaging at NYU Langone Health develop transformative imaging technologies to advance basic science and address unsolved clinical problems.

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