Using advanced MRI methods, we are searching for underlying microstructural and macrostructural brain changes associated with cognitive outcome in patients with mild traumatic brain injury (MTBI).
MTBI is a major public health concern. In this study, we develop and apply advanced diffusion MRI techniques and novel parameter estimation methods to characterize longitudinal microstructural changes. We also investigate the relationship among white matter injury, cortical volume loss, and cognitive outcome following MTBI. Our goal is to identify imaging biomarkers linked to cognitive status, which, when found, will have the potential to play a significant role in improving diagnosis, prognosis, and treatment planning.
Figure 1. White matter ROI analysis reveals significant differences in (left) fractional anisotropy (FA) and (right) intra-axonal diffusivity (Da) between symptom-based subgroups (derived from network analysis) and normal controls. Notably, alterations are observed in the corpus callosum, internal capsules, corona radiata and cingulum– differences not apparent when analyzing the entire MTBI group. Blue indicates regions where NC > MTBI; red indicates NC < MTBI.
Project Lead
Project Lead
We acknowledge support from the following grants: NIH R01 NS119767-01A1, R01 NS039135-11, R56 NS119767, and DoD grant PT190013.
Researchers at the Center for Biomedical Imaging at NYU Langone Health develop transformative imaging technologies to advance basic science and address unsolved clinical problems.
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