Faculty

Contact Information
  • dmitry.novikov@nyulangone.org
  • 212-263-2718

Dmitry Novikov, PhD

Associate Professor
I use analytical and numerical modeling tools to quantify and interpret cellular-level tissue structure and its changes in disease based on various MRI contrasts. Biophysical modeling of diffusion and NMR relaxation makes it possible to become specific to tissue features 100-1000 times below the nominal MRI resolution. Specifically, I focus on MRI measurements of diffusion, transverse relaxation, and perfusion, to quantify cell structure and size, membrane permeability, and accumulated iron, and to identify quantitative disease biomarkers in neurodegenerative diseases, tumors, and myopathies.

Research Projects

Multi-Scale and Multi-Modality Imaging of Neuropathology in VCID

This study aims to advance understanding of neurodegeneration in VCID by developing postmortem MRI protocols, computational tools, and multi-modal atlases, standardizing MRI and histology methods, and creating extensive imaging and biomaterial resources to support research in AD, ADRD, and related pathologies.

AGING   BRAIN

Neuroimaging Core of NYU Langone’s Alzheimer’s Disease Research Center

The neuroimaging core of NYU Langone’s Alzheimer Disease Research Center supports research on Alzheimer’s and related dementias by developing and applying advanced imaging techniques to aid early diagnosis, track disease progression, and inform novel diagnostics and treatments.

AGING   BRAIN

Unpacking the Importance of the Structural Injuries in Mild Traumatic Brain Injury

This project uses advanced diffusion MRI techniques and novel analysis methods to identify imaging biomarkers of brain changes and cognitive outcomes in patients with mild traumatic brain injury, aiming to improve diagnosis, prognosis, and treatment planning.

BRAIN   DIFFUSION MRI

Brain Microstructure Imaging

This project develops and validates biophysical models of diffusion and nuclear magnetic resonance relaxation to quantify tissue microstructure in the brain—such as axonal integrity, inflammation, fiber orientation dispersion, axonal diameters, axonal beading, undulations, and water exchange—using diffusion methods and a leading-edge Siemens Connectom.X gradient system.

BRAIN   DIFFUSION MRI

Researchers at the Center for Biomedical Imaging at NYU Langone Health develop transformative imaging technologies to advance basic science and address unsolved clinical problems.

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