This project aims to develop an ultra-high-resolution USPIO-enhanced MRI technique to visualize the brain's microvascular architecture, quantify vascular density, and investigate age-related neurovascular changes, potentially advancing the understanding of microvascular aging and its role in neurologic disorders.

This study aims to advance understanding of neurodegeneration in VCID by developing postmortem MRI protocols, computational tools, and multi-modal atlases, standardizing MRI and histology methods, and creating extensive imaging and biomaterial resources to support research in AD, ADRD, and related pathologies.