This study aims to advance understanding of neurodegeneration in VCID by developing postmortem MRI protocols, computational tools, and multi-modal atlases, standardizing MRI and histology methods, and creating extensive imaging and biomaterial resources to support research in AD, ADRD, and related pathologies.
This study uses advanced MRI techniques to investigate how sleep and aging affect cerebrospinal fluid clearance in healthy individuals and Alzheimer’s patients, aiming to understand the glymphatic system’s role in brain health and disease progression.