Projects

Neural Underpinning of Cognitive and Behavioral Deficits in Psychotic Spectrum Disorders

This research uses a multi-modal approach to reveal the neural mechanisms underlying psychotic spectrum disorders and to provide objective biomarkers for assessing disease progression and treatment efficacy.

BRAIN   DIFFUSION MRI

Brain Microstructure Imaging

This project develops and validates biophysical models of diffusion and nuclear magnetic resonance relaxation to quantify tissue microstructure in the brain—such as axonal integrity, inflammation, fiber orientation dispersion, axonal diameters, axonal beading, undulations, and water exchange—using diffusion methods and a leading-edge Siemens Connectom.X gradient system.

BRAIN   DIFFUSION MRI   MICROSTRUCTURE

Understanding CSF Clearance in Aging and Alzheimer’s Brain Through Dynamic Sodium MRI

This study uses advanced MRI techniques to investigate how sleep and aging affect cerebrospinal fluid clearance in healthy individuals and Alzheimer’s patients, aiming to understand the glymphatic system’s role in brain health and disease progression.

AGING   BRAIN   X-NUCLEI

Unpacking the Importance of the Structural Injuries in Mild Traumatic Brain Injury

This project uses advanced diffusion MRI techniques and novel analysis methods to identify imaging biomarkers of brain changes and cognitive outcomes in patients with mild traumatic brain injury, aiming to improve diagnosis, prognosis, and treatment planning.

BRAIN   DIFFUSION MRI

Multi-Scale and Multi-Modality Imaging of Neuropathology in VCID

This study aims to advance understanding of neurodegeneration in VCID by developing postmortem MRI protocols, computational tools, and multi-modal atlases, standardizing MRI and histology methods, and creating extensive imaging and biomaterial resources to support research in AD, ADRD, and related pathologies.

AGING   BRAIN
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Researchers at the Center for Biomedical Imaging at NYU Langone Health develop transformative imaging technologies to advance basic science and address unsolved clinical problems.

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