This research investigates early mechanisms of abnormal brain aging and validates early biomarkers to identify pre-symptomatic stages before clinical symptoms appear.

This project aims to develop an ultra-high-resolution USPIO-enhanced MRI technique to visualize the brain's microvascular architecture, quantify vascular density, and investigate age-related neurovascular changes, potentially advancing the understanding of microvascular aging and its role in neurologic disorders.

The neuroimaging core of NYU Langone’s Alzheimer Disease Research Center supports research on Alzheimer’s and related dementias by developing and applying advanced imaging techniques to aid early diagnosis, track disease progression, and inform novel diagnostics and treatments.

This project investigates intracellular viscosity as a potential early marker of neurodegeneration and Alzheimer’s disease by combining PET imaging, blood-based biomarkers, and an innovative technique called magnetic resonance spectroscopic fingerprinting (MRSF), using data from a well-characterized cohort at NYU’s Alzheimer’s Disease Research Center.