Projects

Cellular Viscosity as a Marker for Alzheimer’s Disease Pathology: A Combined Multiparametric MR Spectroscopy and PET Study

This project investigates intracellular viscosity as a potential early marker of neurodegeneration and Alzheimer’s disease by combining PET imaging, blood-based biomarkers, and an innovative technique called magnetic resonance spectroscopic fingerprinting (MRSF), using data from a well-characterized cohort at NYU’s Alzheimer’s Disease Research Center.

AGING   BRAIN

Breast cancer Intravoxel Incoherent Motion Multisite (BRIMM) Project

The BRIMM project is a multi-site breast cancer study using intravoxel incoherent motion (IVIM) MRI to develop a robust, cross-platform imaging biomarker that noninvasively characterizes the tumor microenvironment and predicts response to neoadjuvant chemotherapy.

BREAST   DIFFUSION MRI

Multinuclear Fingerprinting

This project develops a noninvasive MRI technique called multinuclear fingerprinting (MNF) at 7 T, combining hydrogen (1H) and sodium (23Na) magnetic resonance fingerprinting with a super-resolution algorithm to create multi-parametric structural and metabolic maps of the human brain, offering insights into its morphology, physiology, and disorders.

QUANTITATIVE MRI   X-NUCLEI

Multi-Scale and Multi-Modality Imaging of Neuropathology in VCID

This study aims to advance understanding of neurodegeneration in VCID by developing postmortem MRI protocols, computational tools, and multi-modal atlases, standardizing MRI and histology methods, and creating extensive imaging and biomaterial resources to support research in AD, ADRD, and related pathologies.

AGING   BRAIN

Tissue Microstructure Imaging in the Body

This project develops and validates biophysical models of diffusion and nuclear magnetic resonance relaxation to quantify microstructural properties in muscle tissue and the prostate using methods for estimating physiological properties, the random permeable barrier model, and diffusion relaxometry acquisitions.

BRAIN   DIFFUSION MRI
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Researchers at the Center for Biomedical Imaging at NYU Langone Health develop transformative imaging technologies to advance basic science and address unsolved clinical problems.

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