Projects

Tissue Microstructure Imaging in the Body

This project develops and validates biophysical models of diffusion and nuclear magnetic resonance relaxation to quantify microstructural properties in muscle tissue and the prostate using methods for estimating physiological properties, the random permeable barrier model, and diffusion relaxometry acquisitions.

BRAIN   DIFFUSION MRI   MICROSTRUCTURE

Breast cancer Intravoxel Incoherent Motion Multisite (BRIMM) Project

The BRIMM project is a multi-site breast cancer study using intravoxel incoherent motion (IVIM) MRI to develop a robust, cross-platform imaging biomarker that noninvasively characterizes the tumor microenvironment and predicts response to neoadjuvant chemotherapy.

BREAST   DIFFUSION MRI

In Vivo Insights into Aging-Related Small-Vessel Changes Using USPIO-Enhanced MRI

This project aims to develop an ultra-high-resolution USPIO-enhanced MRI technique to visualize the brain's microvascular architecture, quantify vascular density, and investigate age-related neurovascular changes, potentially advancing the understanding of microvascular aging and its role in neurologic disorders.

AGING   BRAIN

Cellular Viscosity as a Marker for Alzheimer’s Disease Pathology: A Combined Multiparametric MR Spectroscopy and PET Study

This project investigates intracellular viscosity as a potential early marker of neurodegeneration and Alzheimer’s disease by combining PET imaging, blood-based biomarkers, and an innovative technique called magnetic resonance spectroscopic fingerprinting (MRSF), using data from a well-characterized cohort at NYU’s Alzheimer’s Disease Research Center.

AGING   BRAIN

Overhauser Dynamic Nuclear Polarization of Water Vapor

This project develops an Overhauser dynamic nuclear polarization platform to enhance nuclear magnetic resonance and magnetic resonance imaging signals through efficient electron–nuclear polarization transfer using a custom microwave transmission system, loop-gap resonator, and inhalable hyperpolarized aerosols for high-sensitivity pulmonary imaging at low magnetic fields.

NMR
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Researchers at the Center for Biomedical Imaging at NYU Langone Health develop transformative imaging technologies to advance basic science and address unsolved clinical problems.

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